How do we define therapy-resistant constipation in children aged 4-18 years old? A systematic review with meta-narrative synthesis.
Vassiliki SinopoulouMorris GordonShaman RajindrajithWatshala HathagodaAditi Bhupendra RaneAnita SedghiMerit TabbersCarlo Di LorenzoMiguel SapsMarc A BenningaPublished in: BMJ paediatrics open (2024)
The current literature has no explicit definition for therapy-resistant constipation in children. There is a need for a detailed consensus definition to ensure consistency of future research and to avoid unnecessary and maybe even harmful, invasive diagnostic and therapeutic interventions.