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How do we define therapy-resistant constipation in children aged 4-18 years old? A systematic review with meta-narrative synthesis.

Vassiliki SinopoulouMorris GordonShaman RajindrajithWatshala HathagodaAditi Bhupendra RaneAnita SedghiMerit TabbersCarlo Di LorenzoMiguel SapsMarc A Benninga
Published in: BMJ paediatrics open (2024)
The current literature has no explicit definition for therapy-resistant constipation in children. There is a need for a detailed consensus definition to ensure consistency of future research and to avoid unnecessary and maybe even harmful, invasive diagnostic and therapeutic interventions.
Keyphrases
  • systematic review
  • young adults
  • current status
  • clinical practice
  • bone marrow