Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain.
Matthew BruceKarin M StreifelCasey A BoosalisLuke HeuerEduardo A GonzálezShuyang LiDanielle J HarveyPamela J LeinJudy Van de WaterPublished in: Journal of neuroinflammation (2019)
These findings indicate that genetic background and sex influence the CNS response to an acute peripheral immune challenge during early postnatal development. Additionally, these data reinforce that the developmental time point during which the challenge occurs has a distinct effect on the activation of CNS-resident cells.
Keyphrases
- liver failure
- respiratory failure
- preterm infants
- poor prognosis
- induced apoptosis
- blood brain barrier
- drug induced
- aortic dissection
- genome wide
- patient safety
- intensive care unit
- signaling pathway
- spinal cord injury
- dna methylation
- deep learning
- cell proliferation
- binding protein
- copy number
- artificial intelligence
- emergency medicine