[Metachronous tumors of the stomach in a patient with autoimmune gastritis].
Nano V PachuashviliD P NagornayaAlexander S TertychnyyPublished in: Arkhiv patologii (2023)
Stomach cancer continues to be a global health problem, ranking 5th among cancers and 4th among the causes of death from cancer in the world. Autoimmune atrophic gastritis is a chronic autoimmune disease characterized by the production of antibodies to parietal cells and intrinsic factor, followed by atrophy of the mucous membrane of the body and fundus of the stomach. Chronic autoimmune inflammation can lead to damage to the genetic apparatus of the cell and trigger a multi-stage process of carcinogenesis. Our article presents an unusual case of three different gastric tumors, including adenocarcinoma with microsatellite instability, in a patient with autoimmune gastritis.
Keyphrases
- multiple sclerosis
- helicobacter pylori
- drug induced
- global health
- helicobacter pylori infection
- papillary thyroid
- oxidative stress
- induced apoptosis
- public health
- squamous cell carcinoma
- young adults
- childhood cancer
- dna methylation
- cell therapy
- cell death
- cell cycle arrest
- diabetic retinopathy
- signaling pathway
- copy number
- optical coherence tomography
- rectal cancer
- genetic diversity