Effects of colchicine in adults with metabolic syndrome: A pilot randomized controlled trial.
Andrew Paul DemidowichJordan A LevineGinikanwa I OnyekabaShahzaib M KhanKong Y ChenSheila M BradyMiranda M BroadneyJack A YanovskiPublished in: Diabetes, obesity & metabolism (2019)
This pilot study found colchicine significantly improved obesity-associated inflammatory variables and showed a good safety profile among adults with obesity and MetS who did not have diabetes. These results suggest a larger, adequately powered study should be conducted to determine whether colchicine improves insulin resistance and other measures of metabolic health in at-risk individuals.
Keyphrases
- insulin resistance
- metabolic syndrome
- type diabetes
- randomized controlled trial
- high fat diet induced
- high fat diet
- adipose tissue
- study protocol
- glycemic control
- polycystic ovary syndrome
- skeletal muscle
- weight loss
- healthcare
- uric acid
- public health
- cardiovascular disease
- mental health
- cardiovascular risk factors
- oxidative stress
- clinical trial
- weight gain
- body mass index
- physical activity
- risk assessment
- health information
- climate change