Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database.
Pål MøllerToni SeppäläInge BernsteinElke Holinski-FederPaola SalaD Gareth EvansAnnika LindblomFinlay MacraeIgnacio BlancoRolf SijmonsJacqueline JeffriesHans VasenJohn BurnSigve NakkenEivind HovigEinar Andreas RødlandKukatharmini TharmaratnamWouter H de Vos Tot Nederveen CappelJames HillJuul WijnenKate GreenFiona LallooLone SundeMiriam MintsLucio BertarioMarta PinedaMatilde NavarroMonika MorakLaura Renkonen-SinisaloIan M FraylingJohn-Paul PlazzerKirsi PylvanainenJulian R SampsonGabriel CapellaJukka-Pekka MecklinGabriela Mösleinnull nullPublished in: Gut (2015)
The four Lynch syndrome-associated genes had different penetrance and expression. Colorectal cancer occurred frequently despite colonoscopic surveillance but resulted in few deaths. Using our data, a website has been established at http://LScarisk.org enabling calculation of cumulative cancer risks as an aid to genetic counselling in Lynch syndrome.