The FAME trial study protocol: In younger adults with unstable ankle fractures treated with close contact casting, is ankle function not worse than those treated with surgical intervention?
Juul AchtenElsa M R MarquesRafael Pinedo-VillanuevaMichael Richard WhitehouseWilliam G P EardleyMatthew Lee CostaRebecca Samantha KearneyDavid J KeeneXavier Luke GriffinPublished in: Bone & joint open (2024)
The 12-month results will be presented and published internationally. This is anticipated to be the only pragmatic trial reporting outcomes comparing surgical with non-surgical treatment in unstable ankle fractures in younger adults (aged 60 years and younger), and, as such, will inform the National Institute for Health and Care Excellence (NICE) 'non-complex fracture' recommendations at their scheduled update in 2024. A report of long-term outcomes at five years will be produced by January 2027.
Keyphrases
- study protocol
- randomized controlled trial
- healthcare
- clinical trial
- quality improvement
- phase iii
- open label
- public health
- phase ii
- palliative care
- mental health
- placebo controlled
- health information
- type diabetes
- pain management
- meta analyses
- weight loss
- electronic health record
- health insurance
- climate change
- skeletal muscle