A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems.

Spiros DenaxasAnoop D ShahBilal Akhter MateenValerie KuanJennifer K QuintNatalie FitzpatrickAna TorralboGhazaleh FatemifarHarry Hemingway

Published in: JAMIA open (2020)

Bootstrapping phenotyping algorithms from similar EHR can potentially address pre-existing methodological concerns that undermine the outputs of biomarker discovery pipelines and provide research-quality phenotyping algorithms.

Keyphrases

machine learning
primary care
high throughput
electronic health record
deep learning
small molecule
cross sectional
quality improvement
single cell