Bioassay-guided isolation of active anti-adipogenic compound from royal jelly and the study of possible mechanisms.

Prakash Raj PandeyaRamakanta LamichhaneKyung-Hee LeeSe-Gun KimDae-Ho LeeHyeong-Kyu LeeHyun-Ju Jung

Published in: BMC complementary and alternative medicine (2019)

Our results suggest that anti-adipogenesis of 10-HDA on 3 T3-L1 adipocyte takes place via two mechanisms: inhibition of cAMP/PKA pathway and inhibition of p-Akt and MAPK dependent insulin signaling pathway. So it is considered that 10-HDA, a major component of RJ, can be a potential therapeutic medicine for obesity.

Keyphrases

signaling pathway
insulin resistance
type diabetes
pi k akt
high fat diet induced
metabolic syndrome
adipose tissue
epithelial mesenchymal transition
histone deacetylase
induced apoptosis
weight loss
cell proliferation
fatty acid
bone marrow
body mass index
mesenchymal stem cells
protein kinase