EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation.

Weipeng MuJoshua StarmerDella YeeTerry R Magnuson

Published in: Epigenetics & chromatin (2018)

Ezh2's expression is regulated at transcriptional and post-transcriptional levels in a cellular context-dependent manner. EZH2 variants determine functional specificity of PRC2 in histone methylation during cell proliferation and differentiation.

Keyphrases

dna methylation
copy number
transcription factor
long non coding rna
cell proliferation
gene expression
long noncoding rna
genome wide
poor prognosis
heat shock
binding protein