Quassilactones A and B, structural characterization of a new class of norquassinoids from Brucea javanica.
Zhiwei SuZhonghui MaKai LiuTingting LiBo ZhouPublished in: Journal of natural medicines (2020)
Two novel norquassinoids possessing a unique ketal skeleton, designated quassilactones A (1) and B (2), were isolated from the fruits of Brucea javanica (Simaroubaceae). Their structures were established by extensive NMR and HR-ESI-MS spectroscopic analysis. The absolute configuration of 1 was determined through single-crystal X-ray crystallography, and that of 2 was assigned by comparing the calculated electronic and experimental circular dichroism with compound 1. In addition, their cytotoxic activities against three human cancer cell lines and their antimicrobial activities were evaluated.
Keyphrases
- high resolution
- ms ms
- endothelial cells
- papillary thyroid
- mass spectrometry
- magnetic resonance
- staphylococcus aureus
- multiple sclerosis
- solid state
- molecular docking
- squamous cell
- induced pluripotent stem cells
- lymph node metastasis
- pluripotent stem cells
- computed tomography
- young adults
- childhood cancer
- magnetic resonance imaging
- electron microscopy