Cushing's disease due to somatic USP8 mutations: a systematic review and meta-analysis.

Ingrid Quevedo WanichiBeatriz Marinho de Paula MarianiFernando Pereira FrassettoSheila Aparecida Coelho SiqueiraNina Rosa de Castro MusolinoMalebranche Berardo Carneiro Cunha-NetoGilberto OchmanValter Angelo Sperling CescatoMarcio Carlos MachadoEricka Barbosa TrarbachMarcello Delano BronsteinMaria Candida Barisson Villares Fragoso

Published in: Pituitary (2020)

Our data, as well as the retrospective review of CD series associated with USP8-mutated alleles, show heterogeneous findings among the series. Several drawbacks included the lack of a systematic protocol to evaluate these patients before surgery and follow-up. Further prospective studies using a systematic protocol will provide more consistent information about the influence of the corticotropinomas with USP8-mutated alleles on the phenotype, responses to treatment and outcome of patients with CD.

Keyphrases

end stage renal disease
randomized controlled trial
ejection fraction
newly diagnosed
minimally invasive
chronic kidney disease
prognostic factors
peritoneal dialysis
gene expression
nk cells
big data
copy number
acute coronary syndrome
wild type
genome wide
patient reported
smoking cessation