Impact of FAPI-46/dual-tracer PET/CT imaging on radiotherapeutic management in esophageal cancer.

Simone FerdinandusKarina ClausPhilipp LindeJohannes RosenbrockMaike TrommerThomas ZanderArmin TuchschererChristiane BrunsHans Anton SchlößerWolfgang SchröderMarie-Lisa EichThomas FischerKlaus SchomäckerAlexander DrzezgaCarsten KobeKatrin Sabine RothJasmin Josefine Weindler

Published in: Radiation oncology (London, England) (2024)

We report first data on the use of PET with FAPI-46 for patients with EC, who are scheduled to receive RT. Tumor uptake was high and not depending on FAP expression in TME. Further, FAPI-46/dual-tracer PET had relevant impact on management in this setting. Our data calls for prospective evaluation of FAPI-46/dual-tracer PET to improve clinical outcomes of EC.

Keyphrases

pet ct
positron emission tomography
computed tomography
pet imaging
electronic health record
poor prognosis
big data
high resolution
mass spectrometry
binding protein
data analysis
deep learning