Regional hyperperfusion in cognitively normal APOE ε4 allele carriers in mid-life: analysis of ASL pilot data from the PREVENT-Dementia cohort.

Elizabeth Frances McKiernanElijah MakMaria-Eleni DounaviKatie WellsCraig RitchieGuy WilliamsLi SuJohn Tiernan O'Brien

Published in: Journal of neurology, neurosurgery, and psychiatry (2020)

Regional cerebral hyperperfusion in individuals at increased risk of AD in mid-life may be a very early marker of functional brain change related to AD. Increased perfusion may reflect a functional 'compensation' mechanism, offsetting the effects of early neural damage or may itself be risk factor for accelerating spread of degenerative pathology.

Keyphrases

mild cognitive impairment
cognitive decline
oxidative stress
high fat diet
subarachnoid hemorrhage
cerebral ischemia
white matter
randomized controlled trial
cognitive impairment
study protocol
type diabetes
clinical trial
adipose tissue
deep learning