VERICIGUAT RESCUES CYCLIC GUANOSINE MONOPHOSPHATE PRODUCTION IN HUMAN AORTIC VASCULAR SMOOTH MUSCLE CELLS AND AUGMENTS VASORELAXATION IN AORTIC RINGS EXPOSED TO HIGH GLUCOSE.
David PolhemusDiego AlmodielTarek HarbEfthymios ZiogosNuria Amat-CodinaMark RanekLakshmi SanthanamGary GerstenblithThorsten M LeuckerPublished in: bioRxiv : the preprint server for biology (2024)
The sGC sensitizer/stimulator vericiguat restored cGMP production and PKG activity in the setting of HG. Vericiguat enhanced ACh-mediated vasorelaxation in the setting of HG. The findings suggest clinical studies are warranted to investigate the potential of sGC sensitization/stimulation as a therapeutic intervention to improve vascular endothelial-dependent function that is impaired in pro-inflammatory settings that are associated with the development of atherosclerotic disease.
Keyphrases
- endothelial cells
- high glucose
- vascular smooth muscle cells
- aortic valve
- angiotensin ii
- left ventricular
- randomized controlled trial
- pulmonary artery
- fluorescent probe
- nitric oxide
- aortic dissection
- living cells
- mouse model
- aqueous solution
- heart failure
- human health
- protein kinase
- induced pluripotent stem cells
- coronary artery