The Role of Systemic Therapy in Resectable Colorectal Liver Metastases: Systematic Review and Network Meta-Analysis.

Mohamad Bassam B SonbolRabbia SiddiqiPedro Luiz Serrano UsonSurabhi PathakBelal FirwanaGehan BotrusDiana Almader-DouglasDaniel H AhnMitesh J BoradJason StarrJeremy JonesChee-Chee StuckyRory SmootIrbaz Bin RiazTanios Bekaii-Saab

Published in: The oncologist (2022)

This systematic review and NMA of 7 RCTs found that the addition of perioperative systemic treatment for resectable CRLM could improve disease-free survival but not overall survival. Based on the findings, addition of perioperative treatment in resectable CRLM should be individualized weighing the risks and benefits.

Keyphrases

liver metastases
free survival
systematic review
locally advanced
patients undergoing
cardiac surgery
meta analyses
randomized controlled trial
squamous cell carcinoma
stem cells
climate change
mesenchymal stem cells
combination therapy