Imaging Fibrogenesis in a Diet-Induced Model of Nonalcoholic Steatohepatitis (NASH).
S V HartimathR BoominathanV SohP ChengX DengY C ChongF F YongP W TanW HanE G RobinsJulian L GoggiPublished in: Contrast media & molecular imaging (2019)
The diet-induced progression of liver fibrosis was confirmed using histology and correlated well with the mRNA of integrin α v β 3 and extracellular matrix protein expression. [18F]FtRGD showed very good correlation between liver uptake and integrin α v β 3 expression and similar detection sensitivity to the current clinical gold standard modalities for staging of liver fibrosis.