Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Michela TerlizziChiara ColarussoIlaria De RosaPasquale SommaCarlo CurcioRita P AquinoLuigi PanicoRosario SalviFederica Zito MarinoGerardo BottiAldo PintoRosalinda SorrentinoPublished in: Journal of experimental & clinical cancer research : CR (2020)
We identified a subgroup of NSCLC patients as caspase-4 positive among which double and triple positive caspase-4, K-Ras and/or c-MyC patients which prognosis was poor. Because K-Ras and c-MyC are still undrugable, the identification of caspase-4 as a novel oncoprotein could introduce novelty in the clinical yet unmet needs for NSCLC patients.