Proprotein convertase subtilisin/kexin type 9 regulates the production of acute-phase reactants from the liver.

Dafne Jacome SanzAnni K SaralahtiMeeri PekkarinenJuha KesseliMatti NykterMika RämetMarkus J T OjanenMarko Pesu

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

We demonstrate that PCSK9 is not critical for zebrafish survival in a systemic pneumococcal infection. However, PCSK9 deficiency was associated with the lower expression of APR genes in zebrafish and altered the expression of innate immunity genes in a human hepatocyte cell line. Overall, our data suggest an evolutionarily conserved function for PCSK9 in APR in the liver.

Keyphrases

low density lipoprotein
poor prognosis
genome wide
genome wide identification
electronic health record
big data
machine learning
gene expression
genome wide analysis
replacement therapy
deep learning