Long non-coding RNA HOTAIR: A biomarker and therapeutic target in urological tumors.
null AbidaLina EltaibBshayer Hmdan AlhazmiAbdullah R AlzahraniSyed Mohammed Basheeruddin AsdaqAbuzer AliFutoon Jamal AldhafiriWafaa T AlruwailiMarwan Al-HajeiliAltaf A AbdulkhaliqAli A RabaanMohd ImranPublished in: Pathology, research and practice (2024)
Long non-coding RNAs (lncRNAs) significantly influence gene regulation across epigenetic, transcriptional, and post-transcriptional levels through their interactions with DNA, RNA, and proteins. There is growing evidence of lncRNAs' critical roles in the emergence and progression of various diseases, including urological tumors (UTs), such as cancers of the kidney, bladder, and prostate. Research increasingly links lncRNA dysregulation to diverse cellular processes like invasion, metastasis, apoptosis, and chromatin remodeling. Among these, HOTAIR stands out for its pivotal role in oncogenesis, impacting treatment resistance, cell migration, proliferation, survival, and genomic integrity. This review provides an overview of HOTAIR's functions, its identification, and its biological significance. Furthermore, it delves into HOTAIR's involvement in UTs, underlining its potential as a therapeutic target and biomarker for innovative approaches to treating these cancers.
Keyphrases
- long non coding rna
- cell migration
- poor prognosis
- gene expression
- transcription factor
- prostate cancer
- urinary tract
- dna methylation
- oxidative stress
- spinal cord injury
- endoplasmic reticulum stress
- signaling pathway
- network analysis
- circulating tumor
- genome wide identification
- cell death
- nucleic acid
- dna damage
- single molecule
- copy number
- cell cycle arrest
- free survival
- bioinformatics analysis
- pi k akt
- circulating tumor cells