Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer.

Reiri ShimazakiShigetsugu TakanoMamoru SatohMamoru TakadaYoji MiyaharaKosuke SasakiHideyuki YoshitomiShingo KagawaKatsunori FurukawaTsukasa TakayashikiSatoshi KubokiKazuyuki SogawaShinichiro MotohashiFumio NomuraMasaru MiyazakiMasayuki Ohtsuka

Published in: Cellular oncology (Dordrecht) (2021)

Our data indicate that CFB, a key secreted protein, promotes proliferation by preventing cellular senescence and is associated with immunological tumor promotion in PDAC. These findings suggest that CFB may be a potential target for the treatment of PDAC.

Keyphrases

poor prognosis
long non coding rna
dna damage
endothelial cells
stress induced
electronic health record
signaling pathway
big data
binding protein
amino acid
machine learning
combination therapy
climate change
data analysis
deep learning