Spaceflight causes strain-dependent gene expression changes associated with lipid and extracellular matrix dysregulation in the mouse kidney in vivo.

Rebecca H FinchGeraldine VitryKeith SiewStephen B WalshAfshin Behesti Gary Hardiman Willian Abraham da Silveira

Published in: bioRxiv : the preprint server for biology (2024)

Spaceflight has a significant effect on gene expression in the kidney.Responses in the BALB/c indicate milder transcriptomic perturbations than C57BL/6J.Lipid metabolism was altered in both strains of mice.Extracellular matrix metabolism and TGF-β signalling up in BALB/c down in C57BL/6J.Reduced gene expression of hyaluronan synthesis pathway in BALB/c but not in C57BL/6J.

Keyphrases

extracellular matrix
gene expression
dna methylation
escherichia coli
fatty acid
single cell
transforming growth factor
metabolic syndrome
high fat diet induced
skeletal muscle
epithelial mesenchymal transition
signaling pathway
wild type