Comparison of MED 12 gene mutation and microRNA-124 expression in leiomyoma and myometrium of Turkish patients.
Özge Kömürcü KaruserciHüseyin Çağlayan ÖzcanSadrettin PençeHalime Hanım PenceBurcu ÇaykaraSeyhun SucuMete Gürol UğurPublished in: Ginekologia polska (2022)
In recent studies, it has been suggested that MED 12 gene may play an active role in the formation of fibroids. MED12 and β-catenin / Wnt pathway were emphasized, and alternative genetic pathways are sought in fibroid formation. Also, tumour suppressor and oncogenesis effects of microRNAs have been demonstrated in many different studies. Since it is involved in the Wnt pathway, microRNA-124 has been blamed by some previous studies for the formation of fibroids. This study demonstrates that MED12 exon 2 mutations and probably microRNA-124 gene expressions might contribute to uterine leiomyoma pathology.
Keyphrases
- cell proliferation
- genome wide
- copy number
- case control
- end stage renal disease
- stem cells
- ejection fraction
- poor prognosis
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- epithelial mesenchymal transition
- genome wide identification
- gene expression
- patient reported outcomes
- pregnant women
- pregnancy outcomes
- signaling pathway