Hepatic farnesoid X receptor is necessary to facilitate ductular reaction and expression of heme biosynthetic genes.
Angela E DeanEmilian JungwirthKatrin PanzittMartin WagnerSayeepriyadarshini AnakkPublished in: Hepatology communications (2023)
Overall, our data show that hepatic Fxr is necessary to maintain ductular reaction and accumulation of bile plugs. FXR can direct the expression of multiple heme biosynthetic genes. Thus, modulating FXR activity in EPP patients may help alleviate its associated liver disease.
Keyphrases
- poor prognosis
- end stage renal disease
- genome wide
- ejection fraction
- newly diagnosed
- chronic kidney disease
- binding protein
- prognostic factors
- signaling pathway
- long non coding rna
- electronic health record
- genome wide identification
- patient reported outcomes
- deep learning
- genome wide analysis
- patient reported
- electron transfer