The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling.
Haizhu GaoZhongxin LiLijun GanXueying ChenPublished in: Journal of cardiovascular translational research (2024)
Rehabilitation exercise is a crucial non-pharmacological intervention for the secondary prevention and treatment of cardiovascular diseases, effectively ameliorating cardiac remodeling in patients. Exercise training can mitigate cardiomyocyte apoptosis, reduce extracellular matrix deposition and fibrosis, promote angiogenesis, and regulate inflammatory response to improve cardiac remodeling. This article presents a comprehensive review of recent research progress, summarizing the pivotal role and underlying mechanism of rehabilitation exercise in improving cardiac remodeling and providing valuable insights for devising effective rehabilitation treatment programs. Graphical Abstract.
Keyphrases
- extracellular matrix
- left ventricular
- inflammatory response
- high intensity
- physical activity
- cardiovascular disease
- end stage renal disease
- public health
- randomized controlled trial
- skeletal muscle
- heart failure
- chronic kidney disease
- endothelial cells
- type diabetes
- peritoneal dialysis
- cell death
- endoplasmic reticulum stress
- combination therapy
- metabolic syndrome
- patient reported outcomes
- lipopolysaccharide induced
- cardiovascular events
- cardiovascular risk factors
- toll like receptor
- lps induced