The Quest to Define and Target Cellular Senescence in Cancer.
Boshi WangMarco DemariaPublished in: Cancer research (2022)
Cellular senescence represents a double-edged sword in cancer and its therapy. On one side, senescence-associated growth arrest and immunomodulatory properties exert potent antimalignant functions. On the other side, senescence bypass and secretory phenotype are associated with tumor progression and relapse. Recent studies have demonstrated the enormous potential to combine pro- to antisenescence interventions as a new anticancer approach. However, the heterogeneity of senescence-associated features makes definition and targeting of therapy-induced senescent cells a challenging task. Here, we describe these challenges and discuss how to exploit senescence-associated features to improve treatment efficacy and tolerability.
Keyphrases
- dna damage
- endothelial cells
- stress induced
- papillary thyroid
- high glucose
- squamous cell
- randomized controlled trial
- induced apoptosis
- anti inflammatory
- squamous cell carcinoma
- clinical trial
- cell cycle
- climate change
- open label
- single cell
- replacement therapy
- study protocol
- drug induced
- double blind
- combination therapy