Differences in whole-brain metabolism are associated with the expression of genes related to neurovascular unit integrity and synaptic plasticity in temporal lobe epilepsy.

Ling Xiao Yongxiang TangChijun DengJian LiRong LiHaoyue ZhuDanni GuoZhiquan YangHongyu LongLi FengShuo Hu

Published in: European journal of nuclear medicine and molecular imaging (2023)

Our findings, combined with the analysis of neuroimaging and transcriptional data, suggest that genes related to NVU integrity and synaptic plasticity may drive alterations to brain metabolism that mediate the genetic risk of TLE.

Keyphrases

genome wide
temporal lobe epilepsy
resting state
white matter
poor prognosis
gene expression
bioinformatics analysis
functional connectivity
dna methylation
cerebral ischemia
binding protein
machine learning
brain injury
data analysis