Has the therapeutical ceiling been reached in Crohn's disease randomized controlled trials? A systematic review and meta-analysis.

Fernando MagroPaula Leão MoreiraGaia CatalanoCatarina AlvesFernando Magro Maria Manuela EstevinhoIsabel SilvaAxel U Dignass Laurent Peyrin BirouletSilvio DaneseVipul JairathClaudia Camila DiasMafalda Santiago

Published in: United European gastroenterology journal (2023)

Our review highlights that the odds of clinical outcomes in CD patients receiving biological treatment relative to placebo have been stable in the last decades.

Keyphrases

randomized controlled trial
systematic review
double blind
combination therapy
meta analyses