Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers.

Qin ChenBradley F BoeveNirubol TosakulwongTimothy LesnickDanielle BrushaberChristina DheelJulie FieldsLeah ForsbergRalitza GavrilovaDebra GearhartDana HaleyJeffrey L GunterJonathan Graff-RadfordDavid JonesDavid KnopmanNeill Graff-RadfordRuth KraftMaria LapidRosa RademakersZbigniew K WszolekHowie RosenAdam L BoxerKejal Kantarci

Published in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2019)

Our findings support the potential use of longitudinal 1 H MRS for monitoring the neurodegenerative progression in MAPT mutation carriers starting from the asymptomatic stage.

Keyphrases

high resolution
white matter
resting state
single molecule
cross sectional
amyotrophic lateral sclerosis
multiple sclerosis
human health
computed tomography
mass spectrometry