Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1-phosphate in extravillous trophoblasts.

Kirti R ChaharVijay KumarPhulwanti K SharmaDaniela Brünnert Vibha KaushikPragya GehlotIndu ShekhawatSuman KumarAjay Kumar SharmaSandhya KumariPankaj Goyal

Published in: Reproductive medicine and biology (2021)

SPHKs negatively regulate the expression of MMP1, MMP3, and TIMP3. The level of intracellular S1P acts as a negative feedback switch for MMP1, MMP3, and TIMP3 expression in EVT cells.

Keyphrases

poor prognosis
cell migration
induced apoptosis
binding protein
long non coding rna
genome wide
dna methylation
cell cycle arrest
signaling pathway