Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1-phosphate in extravillous trophoblasts.
Kirti R ChaharVijay KumarPhulwanti K SharmaDaniela BrünnertVibha KaushikPragya GehlotIndu ShekhawatSuman KumarAjay Kumar SharmaSandhya KumariPankaj GoyalPublished in: Reproductive medicine and biology (2021)
SPHKs negatively regulate the expression of MMP1, MMP3, and TIMP3. The level of intracellular S1P acts as a negative feedback switch for MMP1, MMP3, and TIMP3 expression in EVT cells.