Impact of Genomic Alterations on Efficacy of Trastuzumab Deruxtecan Against Human Epidermal Growth Factor Receptor-2-Positive Advanced Gastric Cancer.
Kyoko YamaguchiMamoru ItoTaichi IsobeSakuya KoreishiRyosuke TaguchiKoki UeharaShohei UenoTakashi ImajimaTakafumi KitazonoKenji TsuchihashiHirofumi OhmuraTomoyasu YoshihiroKenro TanoueSatoshi NishiyoriEiji IwamaTakahiro MaedaKoichi AkashiEishi BabaPublished in: JCO precision oncology (2024)
-activating mutation may also attenuate T-DXd efficacy in HER2-positive G/GEJ cancer.