Antioxidant supplements promote tumor formation and growth and confer drug resistance in hepatocellular carcinoma by reducing intracellular ROS and induction of TMBIM1.

Vanilla Xin ZhangKaren Man-Fong SzeLo-Kong ChanDaniel Wai-Hung HoYu-Man TsuiYung-Tuen ChiuEva LeeAbdullah HusainHongyang HuangLu TianCarmen Chak-Lui WongIrene Oi Lin Ng

Published in: Cell & bioscience (2021)

Our data implicate that exogenous antioxidants NAC and GSH, by reducing the intracellular ROS levels and inducing TMBIM expression, promoted HCC formation and tumor growth, and counteracted the therapeutic effect of Sorafenib. Our study provides scientific insight regarding the use of exogenous antioxidant supplements in cancers.

Keyphrases

reactive oxygen species
oxidative stress
dna damage
cell death
poor prognosis
anti inflammatory
transcription factor
electronic health record
machine learning
long non coding rna
binding protein
artificial intelligence