Sex-Specific Reduction in Inflammation of Osteoarthritic Human Chondrocytes and Nutraceutical-Dependent Extracellular Matrix Formation.

Alia H Mallah Mahmoud Amr Haneen Abusharkh Bernard Van Wie Arda GozenJuana MendenhallEdwin TingstadVincent Idone Nehal I Abu-Lail

Published in: Journal of immunology and regenerative medicine (2021)

A sex-dependent response of osteoarthritic chondrocytes to nutraceutical treatment was evident. Our results suggest the use of G for female cells and Alpha for male cells in OA applications seems to be favorable in reducing inflammation and enhancing chondrocytes' ability to form AC tissues.

Keyphrases

extracellular matrix
induced apoptosis
oxidative stress
cell cycle arrest
endothelial cells
gene expression
replacement therapy
pluripotent stem cells