A Potential Role of Semaphorin 3A during Orthodontic Tooth Movement.
Sinan ŞenChristopher J LuxRalf ErberPublished in: International journal of molecular sciences (2021)
Sema3A, its receptors and Osterix are regulated by mechanical forces in hPDLF. SEMA3A upregulation was associated with Osterix (SP7) modulation. Sema3A-enhanced osteogenic marker gene expression in hOB might be dependent on a pathway involving Rac1GTPase and β-catenin. Thus, Semaphorin 3A might contribute to bone remodeling during induced tooth movement.
Keyphrases
- gene expression
- cell proliferation
- mesenchymal stem cells
- dna methylation
- high glucose
- bone marrow
- bone mineral density
- epithelial mesenchymal transition
- poor prognosis
- diabetic rats
- signaling pathway
- drug induced
- oral health
- soft tissue
- oxidative stress
- long non coding rna
- cell migration
- bone regeneration
- body composition
- postmenopausal women