Tolerability considerations for gonadotropin-releasing hormone analogues for endometriosis.

Luigi Della Corte Fabio BarraAntonio MercorioGiulio Evangelisti Agnese Maria Chiara Rapisarda Simone FerreroGiuseppe BifulcoPierluigi Giampaolino

Published in: Expert opinion on drug metabolism & toxicology (2020)

Side effects of long term GnRH-a treatment are particularly relevant. Although it has been known the efficacy of GnRH-as for treating endometriosis-associated pain, the best schedules of therapy in terms of duration and dosages are still to be defined. The ideal treatment schedule of GnRH-a is still a matter of debate as to the optimal add-back combination.

Keyphrases

chronic pain
randomized controlled trial
stem cells
open label
bone marrow
spinal cord injury
placebo controlled