Two Distinctive POMC Promoters Modify Gene Expression in Cushing Disease.
Takako ArakiYukiko ToneMasaaki YamamotoHiraku KamedaAnat Ben-ShlomoShozo YamadaAkira TakeshitaMasato YamamotoYasuhiko KawakamiMasahide ToneShlomo MelmedPublished in: The Journal of clinical endocrinology and metabolism (2021)
We identified a second POMC promoter regulated by methylation status in ACTH-secreting pituitary tumors. Our findings open new avenues for elucidating subcellular regulation of the hypothalamic-pituitary-adrenal axis and suggest the second POMC promoter may be a target for therapeutic intervention to suppress excess ACTH production.