Two Distinctive POMC Promoters Modify Gene Expression in Cushing Disease.

Takako ArakiYukiko ToneMasaaki YamamotoHiraku KamedaAnat Ben-ShlomoShozo YamadaAkira TakeshitaMasato Yamamoto Yasuhiko KawakamiMasahide ToneShlomo Melmed

Published in: The Journal of clinical endocrinology and metabolism (2021)

We identified a second POMC promoter regulated by methylation status in ACTH-secreting pituitary tumors. Our findings open new avenues for elucidating subcellular regulation of the hypothalamic-pituitary-adrenal axis and suggest the second POMC promoter may be a target for therapeutic intervention to suppress excess ACTH production.

Keyphrases

gene expression
dna methylation
genome wide
randomized controlled trial
growth hormone
transcription factor
minimally invasive