Diffusion Magnetic Resonance Imaging Detects Progression in Parkinson's Disease: A Placebo-Controlled Trial of Rasagiline.

David J ArpinTrina MitchellDerek B ArcherRoxana G BurciuWinston T ChuHanzhi GaoThomas J GuttusoChristopher W HessSong LaiIrene A MalatyNikolaus R McFarlandOfer PasternakCatherine C PriceAparna Wagle ShuklaSamuel S WuMichael S OkunDavid E Vaillancourt

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

We found no evidence that 1 mg/day rasagiline has a disease-modifying effect in PD over 1 year. We found pSN free-water increased over 1 year, and baseline free-water relates to clinical motor progression, demonstrating the importance of diffusion imaging parameters for detecting and predicting PD progression. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

magnetic resonance imaging
high resolution
computed tomography
randomized controlled trial
study protocol
clinical trial
double blind