Non-coding RNA genes modulate PI3K/AKT signaling pathway in polycystic ovary syndrome.
Heba S OmarOsama Ahmed IbrahimMaha Gomaa SayedEman Mohammed FarukHanan FouadMiriam SafwatPublished in: Molecular biology reports (2023)
miRNA486 and miRNA483 downregulation may contribute to the etiology of PCOS, influence glucose metabolism, and result in IR in PCOS. Metformin's upregulation of those miRNAs affects glucose metabolism by controlling the expression of GLUT4, ameliorates PCOS-related insulin resistance, and improves PCOS-related hormonal imbalance by controlling the PI3K/AKT signaling pathway.
Keyphrases
- polycystic ovary syndrome
- signaling pathway
- pi k akt
- insulin resistance
- cell proliferation
- cell cycle arrest
- induced apoptosis
- epithelial mesenchymal transition
- poor prognosis
- high fat diet
- metabolic syndrome
- adipose tissue
- skeletal muscle
- type diabetes
- high fat diet induced
- genome wide
- mouse model
- gene expression
- dna methylation
- drug induced
- binding protein
- endoplasmic reticulum stress
- transcription factor