Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia-Analyses from the LACE randomised controlled trial.

Tufail BashirMarcus AchisonSimon AdamsonAsangaedem AkpanTerry AsprayAlison AvenellMargaret M BandLouise A BurtonVera CvoroPeter T DonnanGordon W DuncanJacob GeorgeAdam L GordonCelia L GregsonAdrian HapcaCheryl HumeThomas A JacksonSimon KerrAlixe KilgourTahir MasudAndrew McKenzieEmma McKenzieHarnish PatelKristina PilvinyteHelen C RobertsChristos RossiosAvan A SayerKaren T SmithRoy Louis SoizaClaire J StevesAllan D StruthersDivya TiwariJulie WhitneyMiles D WithamPaul R Kemp

Published in: PloS one (2023)

These data suggest that polymorphic variation in the ACVR1B locus could be associated with body composition in older males. The activin/myostatin pathway might offer a novel potential target to prevent fat accumulation in older individuals.

Keyphrases

body composition
community dwelling
resistance training
bone mineral density
middle aged
physical activity
study protocol
adipose tissue
skeletal muscle
randomized controlled trial
clinical trial
electronic health record
machine learning
deep learning
human health
artificial intelligence
postmenopausal women