cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection.
Chan-Wang Jerry LioBryan McDonaldMariko TakahashiRekha DhanwaniNikita SharmaJenny HuangElise PhamChris A BenedictSonia SharmaPublished in: Journal of virology (2016)
Cytomegalovirus (CMV) is one of the most common viral pathogens, with the majority of people contracting the virus in their lifetime. Although acute infection is mostly asymptomatic in healthy persons, significant pathology is observed in immunocompromised individuals, and chronic CMV infection may exacerbate a myriad of inflammatory conditions. Here we show that primary human endothelial cells mount robust IFN-I responses against CMV via a cGAS/STING/IRF3 pathway. Disruption of STING expression by CRISPRs revealed an essential role in eliciting IFN-I responses and restricting CMV replication. Consistently, in mice, STING is necessary for the first phase of IFN-I production that limits early CMV replication. Our results demonstrate a pivotal role for the cGAS-STING pathway in the initial detection of CMV infection.
Keyphrases
- endothelial cells
- immune response
- dendritic cells
- oxidative stress
- poor prognosis
- sars cov
- respiratory failure
- type diabetes
- epstein barr virus
- skeletal muscle
- metabolic syndrome
- gram negative
- insulin resistance
- vascular endothelial growth factor
- long non coding rna
- high fat diet induced
- label free
- antimicrobial resistance
- innate immune