WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome.

Yuyao TianSofie LautrupPatrick Wai Nok LawNgoc-Duy DinhEvandro Fei FangWai Yee Chan

Published in: Cell & bioscience (2024)

Our findings unravel a new mechanism for the influence of WRN in the early stage of adipogenesis and provide a possible treatment for metabolic dysfunction in WS. These data provide promising insights into potential therapeutics for ageing and ageing-related diseases.

Keyphrases

early stage
adipose tissue
insulin resistance
small molecule
oxidative stress
electronic health record
fatty acid
case report
squamous cell carcinoma
type diabetes
big data
combination therapy
human health
risk assessment