We found that the expression of miR-29a-3p was significantly down-regulated in the vertebral body and disc lesion tissues of patients with spinal tuberculosis. Overexpression of miR-29a-3p inhibited the levels of inflammatory factors including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), and inhibition of miR-29a-3p expression promoted the release of the levels of TNF-α, IL-1β and IL-6 inflammatory factors. Our study also shows that knockout of methyltransferase 3 (METTL3) can significantly reduce the expression of miR-29a-3p and promote the release of pro-inflammatory cytokines in macrophages.
Keyphrases
- poor prognosis
- rheumatoid arthritis
- inflammatory response
- mycobacterium tuberculosis
- spinal cord
- oxidative stress
- gene expression
- transcription factor
- emergency department
- long non coding rna
- lipopolysaccharide induced
- spinal cord injury
- postmenopausal women
- anti inflammatory
- hepatitis c virus
- adverse drug
- hiv infected
- electronic health record
- antiretroviral therapy