Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples.
Ling LengRuiyuan CaoJie MaDanlei MouYunping ZhuWei LiLuye LvDunqin GaoShikun ZhangFeng GongLei ZhaoBintao QiuHaiping XiangZhongjie HuYingmei FengYan DaiJiang ZhaoZhihong WuHongjun LiXinbo ZhouPublished in: Signal transduction and targeted therapy (2020)
The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues. We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism, blood coagulation, immune response, angiogenesis, and cell microenvironment regulation. Several inflammatory factors were upregulated, which was possibly caused by the activation of NF-κB signaling. Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered. Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection, and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic.
Keyphrases
- sars cov
- coronavirus disease
- respiratory syndrome coronavirus
- immune response
- global health
- public health
- gene expression
- label free
- healthcare
- emergency department
- oxidative stress
- signaling pathway
- bioinformatics analysis
- dendritic cells
- cardiovascular disease
- single cell
- single molecule
- cardiovascular events
- bone marrow
- high resolution
- cell proliferation
- mesenchymal stem cells
- cell therapy
- community acquired pneumonia
- toll like receptor
- emergency medical