Reno-Protective Effect of Fenofibrate and Febuxostat Against Vancomycin-Induced Acute Renal Injury in Rats: Targeting PPARγ/NF-κB/COX-II and AMPK/Nrf2/HO-1 Signaling Pathways.
Ehab A M El-ShouraSoutyM Z SharkawiLobnaA AbdelzaherBaselA Abdel-WahabYasmineH AhmedAsmaaRamadan Abdel-SattarPublished in: Immunopharmacology and immunotoxicology (2024)
Our findings show that FX, FENO, and their combination regimen have a nephroprotective impact on VCM-induced kidney injury by suppressing oxidative stress, apoptosis, and the inflammatory response. Renal recovery from VCM-induced injury was accomplished by activation of Nrf2/HO-1 signaling and inhibition of NF-κB expression. This study highlights the importance of FX and FENO as effective therapies for reducing nephrotoxicity in VCM-treated patients.
Keyphrases
- oxidative stress
- diabetic rats
- signaling pathway
- pi k akt
- inflammatory response
- induced apoptosis
- lps induced
- dna damage
- high glucose
- end stage renal disease
- ischemia reperfusion injury
- newly diagnosed
- drug induced
- cell cycle arrest
- ejection fraction
- poor prognosis
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- skeletal muscle
- lipopolysaccharide induced
- cell death
- endoplasmic reticulum stress
- cancer therapy
- endothelial cells
- adipose tissue
- staphylococcus aureus
- metabolic syndrome
- cell proliferation
- toll like receptor
- drug delivery