Absent or Mild Coronary Calcium Predicts Low-Risk Stress Test Results and Outcomes in Patients Considered for Flecainide Therapy.
Jeffrey L AndersonStacey KnightRaymond O McCubreyHeidi T MaySteve MasonThomas J BunchDavid B MinMichael J CutlerViet T LeJoseph B MuhlesteinKirk U KnowltonPublished in: Journal of cardiovascular pharmacology and therapeutics (2021)
An easily administered, inexpensive, low radiation CAC scan can identify a subset of flecainide candidates with a low ischemic burden on PET stress testing that rarely needs coronary angiography/intervention and has favorable outcomes. Absent or mild CAC-burden combined with other clinical information may avoid or complement routine stress testing. However, additional, ideally randomized and multicenter trials are indicated to confirm these findings before replacing stress testing with CAC screening in selecting patients for flecainide therapy in clinical practice.
Keyphrases
- end stage renal disease
- clinical practice
- ejection fraction
- chronic kidney disease
- randomized controlled trial
- peritoneal dialysis
- computed tomography
- coronary artery disease
- double blind
- clinical trial
- coronary artery
- stem cells
- radiation therapy
- type diabetes
- patient reported outcomes
- stress induced
- risk factors
- oxidative stress
- bone marrow
- weight loss
- ischemia reperfusion injury
- patient reported
- insulin resistance