Targeting IGF2-IGF1R Signaling to Reprogram the Tumor Microenvironment for Enhanced Viro-Immunotherapy.

Min Hye NohJin Muk KangAlexandra A MillerGrace NguyenMinxin HuangJi Seon ShimAlberto J Bueso-PerezSara A MurphyKimberly A Rivera-CaraballoYoshihiro OtaniEunju KimSeung-Hee YooYuanqing YanYeshavanth Banasavadi-SiddegowdaHiroshi NakashimaE Antonio ChioccaBalveen KaurZhong-Ming ZhaoTae Jin LeeJi Young Yoo

Published in: Neuro-oncology (2024)

This is the first study reporting that oHSV-induced secreted IGF2 exerts a critical role in resistance to oHSV therapy, which can be overcome by oHSV-D11mt as a promising therapeutic advance for enhanced viro-immunotherapy.

Keyphrases

pi k akt
binding protein
growth hormone
diabetic rats
stem cells
emergency department
oxidative stress
drug delivery
mesenchymal stem cells