The T2-FLAIR mismatch sign as a predictor of IDH-mutant, 1p/19q-noncodeleted lower-grade gliomas: a systematic review and diagnostic meta-analysis.

Sang Ik ParkChong Hyun SuhJeffrey P GuenetteRaymond Y HuangHo Sung Kim

Published in: European radiology (2021)

• The pooled sensitivity and specificity of the T2-FLAIR mismatch sign for prediction of IDH-mutant, 1p/19q-noncodeleted lower-grade gliomas were 42% and 100%, respectively. • Four studies reported false positive results. • The pooled correlation coefficient was 0.87, suggesting almost perfect interobserver agreement.

Keyphrases

wild type
high grade
low grade
systematic review
case control
meta analyses
phase iii
randomized controlled trial
clinical trial
study protocol
structural basis