A Drosophila screen identifies a role for histone methylation in ER stress preconditioning.
Katie G OwingsClement Y ChowPublished in: bioRxiv : the preprint server for biology (2023)
knockdown flies demonstrated that Set1, a histone H3 lysine 4 (H3K4) methyltransferase enzyme, is critical for the proper expression of a subset of ER stress genes during preconditioning. Our data indicate that Set1 likely aids in creating a transient transcriptional 'memory' following initial stress that impacts the response to subsequent stress.
Keyphrases
- genome wide
- cerebral ischemia
- dna methylation
- ischemia reperfusion injury
- poor prognosis
- gene expression
- stress induced
- high throughput
- working memory
- transcription factor
- brain injury
- blood brain barrier
- binding protein
- antiretroviral therapy
- machine learning
- oxidative stress
- long non coding rna
- heat shock
- bioinformatics analysis
- genome wide analysis