Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy.

Ping YangYingmei LouZilong GengZhizhao GuoShuo WuYige LiKaiyuan SongTing ShiShasha ZhangJunhao XiongAlex F ChenDali LiWilliam T PuLintai DaYan ZhangKun SunBing Zhang

Published in: Circulation (2024)

Our study unveils the great potential of CRISPR-Cas nucleases with high precision in treating inheritable cardiomyopathy and opens a new avenue for therapeutic management of inherited cardiac diseases.

Keyphrases

crispr cas
genome editing
hypertrophic cardiomyopathy
left ventricular
heart failure
mouse model