Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post-DRE Urines for Quantitation and Genotype Determination.
Joseph J OttoVanessa L CorrellHampus A EngstroemNaomi L HitefieldBrian P MainBrenna AlbrachtTeresa Johnson-PaisLi Fang YangMichael LissPaul C BoutrosThomas KislingerRobin J LeachOliver J SemmesJulius O NyalwidhePublished in: Proteomics. Clinical applications (2020)
The study demonstrates that MS based peptide variant quantitation in urine could be useful in determining patient genotype expression. This assay provides a tool to evaluate the utility of PSA variant (rs17632542) in parallel with current and forthcoming urine biomarker panels.
Keyphrases
- mass spectrometry
- liquid chromatography
- prostate cancer
- ms ms
- high performance liquid chromatography
- solid phase extraction
- gas chromatography
- capillary electrophoresis
- liquid chromatography tandem mass spectrometry
- tandem mass spectrometry
- poor prognosis
- high resolution
- radical prostatectomy
- multiple sclerosis
- simultaneous determination
- high throughput
- long non coding rna