Login / Signup

The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure-Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial.

Tu Ngoc NguyenKatie HarrisMark WoodwardJohn ChalmersMark Emmanuel CooperPavel HametStephen HarrapSimon R HellerStephen MacMahonGiuseppe ManciaMichel MarreNeil PoulterAnthony RogersBryan WilliamsSophia ZoungasClara K ChowRichard I Lindley
Published in: Diabetes care (2021)
It was possible to retrospectively estimate frailty in a trial population, and this FI identified those at higher risk of poor outcomes. Participants with frailty had some attenuation of benefit from intensive glucose-lowering and BP-lowering treatments.
Keyphrases
  • blood pressure
  • community dwelling
  • study protocol
  • phase iii
  • blood glucose
  • clinical trial
  • phase ii
  • heart rate
  • randomized controlled trial
  • open label
  • placebo controlled